Multifaceted aging and rapamycin
نویسندگان
چکیده
منابع مشابه
Multifaceted aging and rapamycin
Aging is commonly defined as a time-dependent loss of physiological integrity, leading to the decline and impair in organism functions and to the increase of risk for cancer and other major age-associated diseases, finally increasing vulnerability to death [1]. During the last decade the intensive search of anti-aging remedies has lead to the conclusion that both the insulin/IGF-like signaling ...
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in the researches being carried out to combat aging using drug therapy. Few specific drugs like Metformin, Rapamycin and Resveratrol have displayed promising results in anti-aging research of mice, fruit fly and worm. Basically these drugs interfere genetically with the important aging pathways such as IIS, TOR, and NAD+ dependent pathway, and results in lifespan extension in a number of specie...
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A recent discovery that rapamycin suppresses a pro-senescent phenotype in progeric cells not only suggests a non-toxic therapy for progeria but also implies its similarity with normal aging. For one, rapamycin is also known to suppress aging of regular human cells. Here I discuss four potential scenarios, comparing progeria with both normal and accelerated aging. This reveals further indication...
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ژورنال
عنوان ژورنال: Aging
سال: 2013
ISSN: 1945-4589
DOI: 10.18632/aging.100575